Life Science Newsletter – 6/25/12

In this issue: how infections spread on airplanes, more on milk, the patient sleeps tonight, worrisome note about walking speed, waist line linked to diabetes risk, cold activates ‘good’ fat, new light on dark chocolate, MIT on infections and cancer,
bugs in your tummy may lead to aches in your legs, fruit flies and ALS, Mayo defines prostate screening, and more…

Freud’s theory of unconscious conflict linked to anxiety symptoms in new U-M brain research

An experiment that Sigmund Freud could never have imagined 100 years
ago may help lend scientific support for one of his key theories, and
help connect it with current neuroscience.

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Infectious disease transmission on aircraft to be studied

A new study is expected to provide the first detailed information on
how infectious diseases may be transmitted onboard commercial airliners.

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DARA BioSciences Announces Launch of Bionect for Treatment of Skin Irritation and Burns Associated With Radiation Therapy for Cancer

DARA BioSciences, Inc. (Nasdaq:DARA) (the “Company” or “DARA”),
an emerging oncology and oncology-support specialty pharmaceutical company, announced the commercial launch of Bionect® for the treatment of skin irritation and burns associated with radiation therapy.

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Popular Weight-loss Surgery Increases Risk of Alcohol Use Disorders, Study Finds

PITTSBURGH – People who receive the most popular weight-loss surgical
procedure are at increased risk of developing symptoms of alcohol use
disorders, University of Pittsburgh Graduate School of Public Health (GSPH) researchers have discovered.

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Study: New Huntington’s Treatment Shows Promise

A new study shows that the compound Coenzyme Q10 (CoQ) reduces oxidative damage, a key finding that hints at its potential to slow the progression of Huntington disease.

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Coronado Biosciences Receives Orphan-Drug Designation From FDA for CNDO-109-Activated Allogeneic Natural Killer Cells for the Treatment of AML

Coronado Biosciences, Inc., (Nasdaq: CNDO), a biopharmaceutical company focused on the development of novel immunotherapy agents for the treatment of autoimmune diseases and cancer, announced that the U.S. Food and Drug Administration (FDA) has granted orphan-drug designation to CNDO-109-Activated Allogeneic Natural Killer Cells (CNDO-109) for “the treatment of acute myeloid leukemia (AML).”

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Advanced Cancers Destined to Recur After Treatment With Single Drugs

Targeted cancer cell therapies using man-made proteins dramatically shrink many tumors in the first few months of treatment, but new research from Johns Hopkins scientists finds why the cells all too often become resistant, the treatment stops working, and the disease returns.

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Hidden Vitamin in Milk Yields Remarkable Health Benefits

NEW YORK — A novel form of vitamin B3 found in milk in small quantities
produces remarkable health benefits in mice when high doses are administered, according to a new study conducted by researchers at Weill Cornell Medical College and the Polytechnic School in Lausanne, Switzerland.

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Diabetes Rates Increase Significantly Among American Youth

Philadelphia, PA — The first analysis of diabetes trends among American
youth reveals that the prevalence of both type 1 and type 2 increased
among young people substantially over the past decade.

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Confused About Prostate Cancer Screening? Mayo Clinic Expert Helps Explain the Latest

ROCHESTER, Minn. — There is a lot of conflicting advice about prostate
cancer screening.

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Diabetes: Tighter Control Of Blood Sugar Prevents Nerve Condition, But At What Risk?

ANN ARBOR, Mich. — Aggressive control of blood sugar levels in diabetes
can help to prevent a painful condition affecting patients’ nerves,
according to a new systematic review in The Cochrane Library by a team
led by a University of Michigan Health System neurologist.

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How Infection Can Lead To Cancer

New MIT study offers comprehensive look at chemical and genetic changes that occur as inflammation progresses to cancer.

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Fruit Flies Reveal Mechanism Behind ALS-Like Disease

Studying how nerve cells send and receive messages, Johns Hopkins scientists have discovered new ways that genetic mutations can disrupt functions in neurons and lead to neurodegenerative disease, including amyotrophic lateral sclerosis (ALS).

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Sick from Your Stomach: Bacterial Changes May Trigger Diseases Like Rheumatoid Arthritis

ROCHESTER, Minn. — The billions of bugs in our guts have a newfound
role: regulating the immune system and related autoimmune diseases such
as rheumatoid arthritis, according to researchers at Mayo Clinic and the
University of Illinois at Urbana-Champaign.

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Pancreatic Cancer Can Run but Not Hide from the Immune System, according to Penn Study

PHILADELPHIA — A study published this week in Cancer Cell from the Perelman School of Medicine and the Abramson Cancer Center at the University of Pennsylvania describes how pancreatic cancer cells produce a protein that attracts immune cells and tricks them into helping cancer cells grow.

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Study Shows Bariatric Surgery Improves Health in Obese Adolescents

A new national study by the University of Miami Miller School of Medicine
shows that bariatric surgery can safely and substantially reduce weight
and related health problems in morbidly obese adolescents, findings that
could change treatment options offered by physicians.

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The Mind’s Eye

Activity in the temporoparietal junction (TPJ) of the human brain could
be the signature of visual perception, according to a study published
online this week in Nature Neuroscience.

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McGill Discovery: Alzheimer’s Drugs Make Bones Stronger

The drugs commonly used to treat memory loss in Alzheimer’s patients
can make bones stronger, according to a recent study led by Faleh Tamimi,
assistant professor at McGill University’s Faculty of Dentistry.

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Joslin Researchers Find ‘Good Fat’ Activated by Cold, Not
Ephedrine

BOSTON — Researchers at Joslin Diabetes Center have shown that while
a type of “good” fat found in the body can be activated by cold
temperatures, it is not able to be activated by the drug ephedrine.

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Fetal Surgery Is Coming of Age

Maternal-fetal care is entering a new era.

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Study Challenges Previously Held Beliefs About The Role Of Genetic Mutations In Colon Cancer Development

SEATTLE — In exploring the genetics of mitochondria – the powerhouse
of the cell – researchers at Fred Hutchinson Cancer Research Center
have stumbled upon a finding that challenges previously held beliefs about
the role of mutations in cancer development.

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Ultrasounds Spot Heart Disease Early in Rheumatoid Arthritis Patients

ROCHESTER, Minn. — Special echocardiograms show promise for early detection of a potentially deadly complication in rheumatoid arthritis: heart disease, Mayo Clinic research shows.

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Meditation Practice May Decrease Risk For Cardiovascular Disease In Teens

AUGUSTA, Ga. — Regular meditation could decrease the risk of developing cardiovascular disease in teens who are most at risk, according to Georgia Health Sciences University researchers.

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Men And Women Respond Differently To Exercise Advertisements

ANN ARBOR, Mich. — A new University of Michigan study finds that overweight men and women responded differently to advertisements about the benefits from exercise.

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“Just Do It!” Not Good Enough for Cancer Patients, UR Researchers Say

Exercise generally helps the nation’s 12 million cancer survivors,
and researchers are working toward being able to prove, with scientific
certainty, that prescriptions for daily yoga or 20 minutes of walking
will likely extend a patient’s survival.

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Possible Benefits Of Dark Chocolate

Daily consumption of dark chocolate could reduce heart attacks and strokes, a study has claimed.

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Advanced Prostate Cancer Slows With New Drug

A new medication proved effective in slowing the spread of metastatic
prostate cancer, while helping to maintain the quality of life, in patients
with advanced disease.

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Advanced Tests Not Always Needed to Uncover Heart Disease

COLUMBUS, Ohio — Despite the age of the technology, exercise stress
tests remain an extremely useful and cost-effective method for detecting
heart disease during a period when many doctors opt for high-tech and
often high-cost testing, according to an Ohio State University Wexner
Medical Center cardiologist.

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Premature Birth Linked To Increased Risk Of Mental Health Problems

One of the largest studies to investigate birth complications and later
mental health has found that premature birth constitutes a single, independent risk factor for a range of severe psychiatric disorders.

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New Breast Cancer Drug Halts Tumor Growth Better Than Standard Therapy

A new cancer treatment that links chemotherapy with an agent that homes in on specific breast cancer cells was significantly better than the current drug regimen at keeping patients’ advanced tumors from progressing, according to results from a Phase III clinical trial led by Kimberly Blackwell, M.D., of the Duke Cancer Institute.

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Large Waist Linked To Diabetes Risk In Overweight Adults

Overweight people with a large waist are just as likely to develop type
2 diabetes later in life as those who are obese, according to results
from the largest international study of its kind to date.

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Sleep Deprivation May Lead To Higher Anxiety Levels, fMRI Scans Show

DARIEN, IL — New research shows that sleep loss markedly exaggerates
the degree to which we anticipate impending emotional events, particularly
among highly anxious people, who are especially vulnerable.

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Keeping Pace: Walking Speed May Signal Thinking Problems Ahead

MINNEAPOLIS — A new study shows that changes in walking speed in late life may signal the early stages of dementia known as mild cognitive impairment (MCI).

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Preclinical Research Shows Normal Gene Hinders Breast Cancer Chemotherapy

Presence of normal p53, a tumor suppressor gene, instead of a mutated
version, makes breast cancer chemotherapy with doxorubicin less effective.

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In the Hospital, the Noisy Hospital, the Patient Sleeps Tonight?

BOSTON, MA — In the hospital it is not only direct patient care, but also the environment that contributes to recovery.

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