| In this issue: when body piercings go wrong, new target for lung cancer, nobody’s perfect says Yale, regulating energy balance, pollution and stroke risk, keys to a broken heart, Johns Hopkins on hearing-aid gap, mood matters during pregnancy, masked heart disease in men, breast feeding and obesity, starve a virus–feed a cure, Popeye proteins, an orange a day…, colon exams save lives says Sloan-Kettering, and more… | |
 An Orange a Day May Keep Stroke at Bay
BOSTON, MA — “Eat your fruits and vegetables” is advice handed down to us since we were children, and medical studies have backed this advice. |
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 Isolation Can Increase Bad Behavior In Kids With ADHD
Kids with ADHD who are rejected by peers suffer from anxiety and are more prone to substance use and delinquency during adolescence, according to University of Alabama at Birmingham-led research published online Feb. 2012, in the Journal of Abnormal Child Psychology. |
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 Threshold Pharmaceuticals Announces Positive Phase 2b Clinical Trial Results of TH-302 in Patients With Pancreatic Cancer
Threshold Pharmaceuticals, Inc. (NASDAQ: THLD) announced that its 214 patient randomized controlled Phase 2b clinical trial evaluating the efficacy and safety of two doses of the investigational agent TH-302 in combination with gemcitabine compared to gemcitabine alone in patients with first-line advanced pancreatic cancer achieved its primary endpoint, with a 63% improvement |
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 Hepatitis C, a Leading Killer, Is Frequently Undiagnosed But Often Curable
Hepatitis C virus – not AIDS-causing HIV – is the leading chronic virus infection leading to death in the United States, and its victims most often are baby boomers. |
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 Breastfeeding Protects Against Asthma Up To Six Years Of Age
Research by the University of Otago in Christchurch and Wellington has shown that breastfeeding of infants has a clear protective effect against children developing asthma or wheezing up to six years of age. |
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 Coronado Biosciences Announces Phase 1 Clinical Trial Results for TSO in Crohn’s Disease
Coronado Biosciences, Inc., (NASDAQ: CNDO), a biopharmaceutical company focused on the development of novel immunotherapy agents for the treatment of autoimmune diseases and cancer, today announced positive results from the Phase 1 clinical trial of TSO (Trichuris suis ova or CNDO-201) in patients with Crohn’s disease. |
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 When Nerve Meets Muscle, Biglycan Seals The Deal
PROVIDENCE, R.I. [Brown University] — A protein that has shown early promise in preventing the loss of muscle function in mouse models of Duchenne muscular dystrophy, has been found in a new study to be a key player in the process of joining nerves to muscles. |
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 “Popeye” Proteins Help The Heart Adapt To Stress
A family of proteins named after Popeye play an essential role in allowing the heart to respond to stress, according to a study published in the Journal of Clinical Investigation. |
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 NW BIO TEAMS WITH THE AMERICAN RED CROSS IN DCVAX® PROGRAM
Northwest Biotherapeutics announced that it has entered into an agreement with the American Red Cross to provide blood collection services through which immune cells are obtained to make DCVax®-L treatments for brain cancer patients. |
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 Revising the “Textbook” on Liver Metabolism Offers New Targets for Diabetes Drugs, According to Penn Study
PHILADELPHIA — A team led by researchers from the Institute for Diabetes, Obesity and Metabolism (IDOM) at the Perelman School of Medicine, University of Pennsylvania, has overturned a “textbook” view of what the body does after a meal. |
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 ‘Acid Test’ for Cervical Cancer
Women infected with human immunodeficiency virus (HIV) constitute one of the populations at highest risk for human papillomavirus-induced cervical cancer. |
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 Hereditary Breast Cancer: Genetic Code Unravelled
Ground-breaking UK-led research has unravelled the complete genetic code of the most common type of hereditary breast cancer for the first time. |
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 Exercise In Early Twenties May Lower Risk Of Osteoporosis
Physical exercise in the early twenties improves bone development and may reduce the risk of fractures later in life, reveals a study of more than 800 Swedish men carried out at the Sahlgrenska Academy. |
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 Scripps Research Scientists Unlock Evolutionary Secret of Blood Vessels
LA JOLLA, CA, — The ability to form closed systems of blood vessels is one of the hallmarks of vertebrate development. |
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| Faulty Fat Sensor Implicated In Obesity And Liver Disease
Defects in a protein that functions as a dietary fat sensor may be a cause of obesity and liver disease, according to a study published in the journal Nature, led by researchers at Imperial College London. |
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 When Body Piercings Go Wrong
CHICAGO — Body piercings have become increasingly popular among young people in the United States, especially in recent years.
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 Salk Researchers Find New Drug Target For Lung Cancer
LA JOLLA,CA — Drugs targeting an enzyme involved in inflammation might offer a new avenue for treating certain lung cancers, according to a new study by scientists at the Salk Institute for Biological Studies. |
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 Benefits Of Hepatitis C Treatment Outweight Costs For Patients With Advanced Disease, Study Shows
A towering $60,000 bill, a year of fierce, flu-like symptoms and a running risk of depression are among the possible costs of two new hepatitis C treatments. |
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 Yale Study Proves Nobody Is Genetically Perfect
Every person carries on average 100 variants that disable genes – yet very few suffer ill effects, an international team of researchers led by Yale University and Wellcome Trust Sanger Institute report in the Feb. issue of the journal Science. |
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 Regulating Energy Balance
Insights into the molecular mechanisms by which a high-fat diet may contribute to early-onset obesity are presented in Nature this week. |
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 Hearing Aid Gap: Millions Who Could Benefit Remain UNtreated
Though an estimated 26.7 million Americans age 50 and older have hearing loss, only about one in seven uses a hearing aid, according to a new study led by Johns Hopkins researchers. |
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 Mood Matters During Pregnancy
While pregnant, women pay particu lar attention to factors such as diet and exercise to ensure their babies are born healthy and develop normally. |
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 Breastfeeding Reduces Risk Of Childhood Obesity
AURORA, Colo. — Children of diabetic pregnancies have a greater risk of childhood obesity, but new research from the Colorado School of Public Health shows breastfeeding can reduce this threat. |
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 Zebrafish May Hold Key To Repairing Serious Eye Conditions
ANN ARBOR, Mich. — University of Michigan Health System research into the mechanisms by which zebrafish are able to regenerate damaged retinas after injury suggests new strategies for one day being able to do the |
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 Starve a Virus, Feed a Cure?
A protein that protects some of our immune cells from the most common and virulent form of HIV works by starving the virus of the molecular building blocks that it needs to replicate, according to research published online in Nature Immunology. |
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 Antibiotics Ineffective For Most Sinus Infections
Antibiotics that doctors typically prescribe for sinus infections do not reduce symptoms any better than an inactive placebo, according to investigators at Washington University School of Medicine in St. Louis. |
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| Masked Heart Problems In Men Could Lead To Sudden Death
The healthy heart movement in recent years has focused largely on heart disease as the No. 1 killer of women. |
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 Researchers Study Mitochondrial Function, Potential New Therapeutic Target for Alzheimer’s disease
(CHICAGO) — Researchers at Rush University Medical Center are conducting an early phase clinical trial of a novel drug therapy for patients with dementia due to Alzheimer’s disease. |
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 Mutation Implicated in ‘Broken’ Heart
For decades, researchers have sought a genetic explanation for idiopathic dilated cardiomy opathy (DCM), a weakening and enlargement of the heart that puts an estimated 1.6 million Americans at risk of heart failure each year. |
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 Even Moderate Air Pollution Can Raise Stroke Risks
BOSTON — Air pollution, even at levels generally considered safe by federal regulations, increases the risk of stroke by 34 percent, Beth Israel Deaconess Medical Center researchers have found. |
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